Translating physical stress into biological signals: precision electro-oncology based on conformational changes of electro-sensitive receptors and parameterized immune remodeling

Engineering notes

Key topics: autonomous driving. See the paper for implementation details and experimental results.

Chinese explanation / 中文解读

中文解读待补充：本站会优先为端到端自动驾驶、BEV感知、3D目标检测、轨迹预测、路径规划、LiDAR感知等高价值论文补充中文说明。

Original abstract

Tumor Treating Fields (TTFields) and pulsed electric fields (PEF) have emerged as a fourth modality in oncological treatment, succeeding surgery, radiotherapy, and pharmacotherapy. However, the fundamental mechanisms through which physical electrical stress is precisely transduced into biochemical signals remain to be fully elucidated. By integrating molecular dynamics simulations, multi-omics profiling, and the latest clinical trial data, this review systematically explores how electric fields, functioning as physical signals, initiate intracellular transduction by inducing conformational kinetic changes in G protein-coupled receptors (GPCRs), such as NPFFR2. Furthermore, we discuss how the modulation of waveform parameters enables the precise programming of apoptosis and pyroptosis patterns, thereby inducing immunogenic cell death (ICD) and activating the cGAS-STING pathway. Additionally, proteomics-based insights are employed to reveal the mechanisms of electric-field-induced compensatory resistance, and the pivotal role of electric fields in remodeling the tumor immune microenvironment and reversing resistance to immune checkpoint inhibitors is discussed. This review aims to provide refined theoretical guidance for the clinical translation of the emerging field of the “electro-immunome”.

Links and sources

• PDF from original source

Comments