Autonomous driving paper index
NLRP12 in cancer: a context-dependent regulator of tumor progression, immunity, and metabolism
One-line summary
NLRP12, a member of the NOD-like receptor family, has traditionally been regarded as an inflammasome-associated regulator of inflammatory signaling.
Engineering notes
Key topics: autonomous driving, control. See the paper for implementation details and experimental results.
Chinese explanation / 中文解读
中文解读待补充：本站会优先为端到端自动驾驶、BEV感知、3D目标检测、轨迹预测、路径规划、LiDAR感知等高价值论文补充中文说明。
Original abstract
NLRP12, a member of the NOD-like receptor family, has traditionally been regarded as an inflammasome-associated regulator of inflammatory signaling. However, accumulating evidence indicates that its role in cancer extends far beyond classical inflammasome biology. Recent studies show that NLRP12 exerts highly context-dependent functions across malignancies, acting as either a tumor suppressor or a tumor promoter depending on tumor type, cellular source, and dominant signaling environment. In inflammation-associated and epithelial malignancies such as colorectal cancer, hepatocellular carcinoma, and triple-negative breast cancer, NLRP12 suppresses tumor progression by restraining noncanonical NF-κB, Wnt/β-catenin, JNK, or canonical NF-κB signaling. In contrast, in gastric cancer, ovarian cancer, glioma, and macrophage-rich tumor ecosystems, NLRP12 has been linked to glycolytic remodeling, lactate-associated epigenetic adaptation, aggressive clinicopathological features, and immune suppression. Mechanistically, NLRP12 has emerged as a multifunctional signaling regulator that connects inflammatory control with oncogenic pathway modulation, metabolic rewiring, tumor-associated macrophage polarization, and PANoptosis-related stress responses. These findings position NLRP12 at the crossroads of tumor progression, immunity, metabolism, and inflammatory cell death. In this review, we summarize the molecular and functional landscape of NLRP12 in cancer, with emphasis on its dual roles in tumor biology, its context-specific mechanisms, and its potential clinical relevance as a biomarker and therapeutic reference point. A deeper cell-resolved and mechanism-oriented understanding of NLRP12 may help redefine this molecule from a conventional innate immune regulator to a context-dependent organizer of tumor ecosystems.
Links and sources
Need this topic turned into a technical roadmap?
Full Self Driving can prepare a custom autonomous driving literature review, code map, dataset map, and B2B technology assessment.
Request B2B research
Comments