Autonomous driving paper index
Linking EMT Dynamics to Cellular Plasticity: YAP/TAZ as Central Regulators Across Physiological and Pathological States
One-line summary
Therefore, we propose a model where YAP/TAZ act as the central molecular hub within the networks governing cellular plasticity and EMT dynamics.
Engineering notes
Key topics: autonomous driving, control. See the paper for implementation details and experimental results.
Chinese explanation / 中文解读
中文解读待补充：本站会优先为端到端自动驾驶、BEV感知、3D目标检测、轨迹预测、路径规划、LiDAR感知等高价值论文补充中文说明。
Original abstract
Cellular plasticity allows organisms to adapt dynamically to both physiological and pathological contexts. Epithelial–mesenchymal transition (EMT) is a well-known example of this plasticity and is now widely recognized as a reversible and highly dynamic spectrum of cellular states rather than a simple binary switch. In this review, we summarize current knowledge on the Hippo pathway transcriptional co-activators YAP and TAZ, focusing on their role as a central hub that integrates mechanical, biochemical and metabolic signals from the microenvironment to control cell fate reprogramming. We discuss how YAP/TAZ interact with EMT-related signaling pathways and transcriptional networks to regulate the acquisition, maintenance and dynamic remodeling of mesenchymal states, as well as hybrid epithelial/mesenchymal (E/M) phenotypes. We also highlight the presence of interconnected feed-forward and feedback regulatory loops within the YAP/TAZ–EMT axis, which contribute to the stabilization of cellular plasticity and support context-dependent transcriptional programs. These mechanisms are involved in key physiological processes, including embryonic development and tissue repair, and in pathological conditions such as organ fibrosis and cancer progression. Therefore, we propose a model where YAP/TAZ act as the central molecular hub within the networks governing cellular plasticity and EMT dynamics. Finally, we discuss how a better understanding of the mechanistic basis of YAP/TAZ-driven EMT may provide a useful framework for the development of therapeutic strategies aimed at modulating cellular plasticity in cancer, fibrotic diseases and regenerative medicine.
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