Autonomous driving paper index
FromHormonalDysregulationtoOvarianCarcinoma:Pathophysiologyof CrampsandFibroidswithInsightsfromAI/MachineLearningand Phytonanotherapeutics
One-line summary
Menstrual cramps, uterine fibroids, andovariancarcinomaarenot seenas independentgynaecologicdisordersbut as stages of a biologically related series which occurs due to chronic destabilization of the estrogen-progesterone homeostasis.
Engineering notes
Key topics: autonomous driving. See the paper for implementation details and experimental results.
Chinese explanation / 中文解读
中文解读待补充：本站会优先为端到端自动驾驶、BEV感知、3D目标检测、轨迹预测、路径规划、LiDAR感知等高价值论文补充中文说明。
Original abstract
Menstrual cramps, uterine fibroids, andovariancarcinomaarenot seenas independentgynaecologicdisordersbut as stages of a biologically related series which occurs due to chronic destabilization of the estrogen-progesterone homeostasis. Chronic steroid-signalingdisequilibriumresults in the activationofNF-κB, COX-2, pro-inflammatory cytokines,prostaglandinF2leadingtouterinehypercontractility,angiogenesis,andcellularproliferation.Thesechanges aremanifestedasdysmenorrhea andbleedingandpromote thegrowthanddevelopment of fibroid.With time, this environment establishes a tumor-promoting pelvic field in genetically or epigenetically predisposed women MELD12/HMGA2changes,BRCA-relatedDNA-repairerrors,estrogenmetabolismorstableDNA-methylation/histone marks that promote the development and progression of epithelial ovarian carcinoma.Molecular, systems-biology, epidemiologic,andclinicaldatacombineddemonstratethatcramps-fibroid-cancercontinuumpathwaysaretheestrogenprogestogen-oxidative-stress network,NF-κB/COX-2/prostaglandin-mediated inflammation, TGF-β-dependent fibrosis andmechanotransduction, and est Themodels of genomic, transcriptomic, epigenomic, andproteomic data stratify patients intohighand lowriskgroups, basedon fibroidgrowthpropensity, level of dysmenorrhea, andprognosis. NanotechnologyTherapeutics:Thenanotechnology-basedtherapeutics,phytonanotherapeutics,e.g.curcumin,resveratrol, quercetin,andgreen-teacatechinstotargetTGF-β/SMAD,IGF,VEGF.Togetherwithmulti-omiccohorts,wearablerealtime feedback, and smartmenstrual diagnostics,AI-enhanceddecisionsupport, andnano-andphytonanotherapeutic trials carriedoutwithhighethical andequity standards, thisparadigmshifts thedisjointed, symptom-basedcare to comprehensive,preventivegynaecologichealth,inwhichcrampsareearlywarningsignals,fibroidsarereversible.
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