Electron compensation‐gated nanomotor for immunomodulation and microenvironment remodeling in bacterial pneumonia therapy

Engineering notes

Key topics: autonomous driving, control. See the paper for implementation details and experimental results.

Chinese explanation / 中文解读

中文解读待补充：本站会优先为端到端自动驾驶、BEV感知、3D目标检测、轨迹预测、路径规划、LiDAR感知等高价值论文补充中文说明。

Original abstract

Abstract Bacterial pneumonia treatment is severely hampered by escalating antibiotic resistance and physiological drug delivery barriers. To address these critical challenges, we report the development of an intelligent biomimetic Janus nanomotor (MAgAu@CM) featuring a built‐in “electronic lock” for spatiotemporally controlled on‐demand therapy. The nanomotor is constructed from a melanin‐supported AgAu alloy and camouflaged with an erythrocyte and platelet hybrid membrane, ensuring prolonged systemic circulation and active inflammation targeting. Crucially, the potent silver component remains therapeutically inert during circulation due to a highly stable electronic compensation mechanism. Upon near‐infrared irradiation at the target infection site, the localized photothermal effect acts as a specific “key.” This thermal intervention not only provides direct hyperthermic ablation of the pathogens but also disrupts the electronic equilibrium, triggering the burst release of bactericidal Ag + for powerful synergistic chemo‐photothermal eradication. Concurrently, this photothermal input overclocks the inherent nanozyme activity of the nanomotor, catalyzing the decomposition of endogenous H 2 O 2 to generate robust oxygen‐driven mechanical propulsion for deep penetration into complex infectious biofilms. Furthermore, this system actively remodels the hostile pathological microenvironment by alleviating local hypoxia and promoting the functional polarization of macrophages toward a tissue‐repairing M2 phenotype. By integrating biomimetic stealth, active navigation, stimuli‐responsive propulsion, and microenvironment remodeling, this multifunctional nanoplatform establishes a highly promising translational paradigm for combating deep‐seated and multidrug‐resistant bacterial infections.

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