Autonomous driving paper index
Crosstalk between lactylation and other post-translational modifications in health and diseases
One-line summary
Abstract The inherent perception of lactate as the byproduct of glycolysis has been transformed by the discovery of lysine lactylation (Kla).
Engineering notes
Key topics: autonomous driving, perception. See the paper for implementation details and experimental results.
Chinese explanation / 中文解读
中文解读待补充：本站会优先为端到端自动驾驶、BEV感知、3D目标检测、轨迹预测、路径规划、LiDAR感知等高价值论文补充中文说明。
Original abstract
Abstract The inherent perception of lactate as the byproduct of glycolysis has been transformed by the discovery of lysine lactylation (Kla). Lactylation modification, a reversible and precise acylation, occurs on both histones and non-histone proteins and directly regulates epigenetics and the diversity of various protein functional activities. Since the discovery of lactylation, it has become evident that lactylation does not act in isolation but often works in conjunction with other post-translational modifications (PTMs) such as acetylation, phosphorylation and ubiquitination. On the one hand, lactylation modification shares the similar enzymes, modified sites and substrates with other acylation modifications, leading to functional crosstalk between them. On the other hand, lactylation or other PTMs could alter the protein conformations, amino acid side chain charges or the occupation of special sites, engaging in cooperative or competitive crosstalk, thereby influencing changes in their modification levels, signal transduction, conformation, re-localization and degradation. However, the underlying molecular mechanisms of the diverse crosstalk between lactylation and other PTMs, as well as their roles in various biological processes, have yet to be fully elucidated. Recent advances in quantitative mass spectrometry, isotope tracing, and integrative multi-omics have enabled more reliable detection and dynamic analysis of lactylation–PTM crosstalk, helping to distinguish causal regulation from metabolic correlation. This review integrates current mechanistic and functional evidence, highlighting the roles of lactylation crosstalk in pathophysiological processes and its implications for health and diseases.
Links and sources
Need this topic turned into a technical roadmap?
Full Self Driving can prepare a custom autonomous driving literature review, code map, dataset map, and B2B technology assessment.
Request B2B research
Comments